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Abstracts


ACR 2015:
A 32-mer Aggrecan Fragment Generated by ADAMTS4/5 and MMP-mediated Cleavage Can Directly Excite Nociceptive Neurons. Miller RE, Miller RJ, Belmadani A, Golub SB, Fosang AJ, Malfait AM. ACR/ARHP Annual Scientific Meeting, San Francisco, CA, Nov 8-11, 2015.

OARSI 2015:
An aggrecan 32-mer fragment generated in osteoarthritis directly excites nociceptive neurons. Miller RE, Miller RJ, Belmadani A, Golub SB, Fosang AJ, Malfait AM. OARSI World Congress, Seattle, WA, April 30-May 3, 2015.

In vivo Calcium Imaging of Knee-Innervating Dorsal Root Ganglion Neurons Reveals Increased Neuronal Responsiveness to Physical Stimuli after DMM Surgery. Miller RE, Park K, Ishihara S, Kim YS, Miller RJ, Dong X, Malfait AM. OARSI World Congress, Seattle, WA, April 30-May 3, 2015.

Inflammatory Protein Profiling in the Knee Joint after DMM Surgery in the Mouse. Miller RE, Tu Z, Tran PB, Qin XC, Luo JF, Tortorella M, Malfait AM. OARSI World Congress, Seattle, WA, April 30-May 3, 2015.

ACR 2014:
A Potential Role for TLR4 Activation in Osteoarthritis Associated Pain. Miller RE, Ishihara S, Tran PB, Miller RJ, Malfait AM. ACR/ARHP Annual Scientific Meeting, Boston, MA, Nov 15-19, 2014.

IASP 2014:
Therapeutic Targeting of Cartilage with ADAMTS-5 Antibodies Reduces Pain in Experimental Osteoarthritis. Miller RE, Tran PB, Ishihara S, Larkin J, Malfait AM. 15th World Congress on Pain, International Association for the Study of Pain, Buenos Aires, Argentina, Oct 6-10, 2014

Paired Amino Acid Converting Enzyme 4 (PACE4): A Gene for Pain on the Left Side of the Body. Wieskopf JS, Webb M, Marcovitz JL, Slepian PM, Geggie-Hurst N, Miller RE, Sotocinal SG, Malfait A, Mogil JS. 15th World Congress on Pain, International Association for the Study of Pain, Buenos Aires, Argentina, Oct 6-10, 2014

OARSI 2014:
Therapeutic Efficacy of Anti-ADAMTS5 Antibody in the DMM Model. Miller RE, Tran PB, Ishihara S, Larkin J, Malfait AM. OARSI World Congress, Paris, France, April 24-27, 2014.

Characterisation of Pain-Related Behaviours in Association with Joint Pathology in an 8-week Antigen-Induced Arthritis Model. Zaki S, Miller RE, Malfait AM, Smith S, Tran PB, Ishihara S, Little C. OARSI World Congress, Paris, France, April 24-27, 2014.

DAMPs Provide a Link Between Joint Tissue Damage and Pain Through Direct Activation of TLR4 Expressed by Sensory Neurons. Miller RE, Tran PB, Ishihara S, Miller RJ, Malfait AM. OARSI World Congress, Paris, France, April 24-27, 2014.

Exploring a Role for the Serine Protease PACE4 in Pain Associated with Experimental OA. Miller RE, Tran PB, Ishihara S, Das R, Malfait AM. OARSI World Congress, Paris, France, April 24-27, 2014.

Pain Pathway Activation in Dorsal Root Ganglia and Dorsal Horn in a Murine Surgical Model of Osteoarthritis. Tran PB, Miller RE, Miller RJ, Malfait AM. OARSI World Congress, Paris, France, April 24-27, 2014.

Establishing a Method for Measuring Primary Knee Hyperalgesia in the Murine DMM Model of Osteoarthritis. Miller RE, Zaki S, Ishihara S, Tran PB, Little C, Malfait AM. OARSI World Congress, Paris, France, April 24-27, 2014.

The Highs and Lows of Translational Drug Development: Antibody-Mediated Inhibition of ADAMTS-5 for Osteoarthritis Disease Modification. Larkin J, Lohr T, Elefante L, Shearin J, Matico R, Su JL, Xue Y, Liu F, Rossman EI, Renninger J, Wu X, Abberley L, Miller RE, Foulcer S, Chaudhary KW, Genell C, Murphy D, Tran PB, Apte S, Malfait AM, Maier CC, Matheny CJ. OARSI World Congress, Paris, France, April 24-27, 2014.

SFN 2013:
Paired amino acid converting enzyme 4 (PACE4): A gene for pain on the left side of the body. Wieskopf JS, Webb ME, Marcovitz J, Miller RE, Slepian P, Sotocinal S, Malfait AM, Mogil JS. Society for Neuroscience Annual Meeting, San Diego, CA, Nov 9-13, 2013.

ACR 2013:
Pain Pathway Activation In Dorsal Root Ganglia and Dorsal Horn In a Murine Surgical Model Of Osteoarthritis. Miller RE, Tran PB, Miller RJ, Malfait AM. ACR/ARHP Annual Scientific Meeting, San Diego, CA, Oct 25-30, 2013.

OARSI 2013:
Investigating a role for TNF-α in MCP-1 upregulation in the knee and DRG in the DMM model. Miller RE, Tran P, Malfait AM. OARSI World Congress, Philadelphia, PA, April 18-21, 2013.

ACR 2012:
Chemokine (C-C Motif) Receptor 2 Signaling Mediates Persistent Pain In Experimental Osteoarthritis. Miller RE, Tran PB, Das R, Ghoreishi-Haack N, Miller RJ, Malfait AM. ACR/ARHP Annual Scientific Meeting, Washington, DC, Nov 9-14, 2012.

IASP 2012:
MCP-1/CCR2 Signaling is Key for Acute-to-Chronic Pain Conversion in a Murine Model of Osteoarthritis. Miller RE, Tran PB, Ghoreishi-Haack N, Malfait AM. 14th World Congress on Pain, International Association for the Study of Pain, Milan, Italy, Aug 27-31, 2012

ACR 2011:
Destabilization of the Medial Meniscus as a Model to Study the Relationship Between Joint Degeneration and Pain. Miller RE, Tran P, Ghoreishi-Haack N, Das R, Malfait AM. ACR/ARHP Annual Scientific Meeting, Chicago, IL, Nov 4-9, 2011.

AAPS 2011:
Nanoparticles for Improved Local Retention After Intra-articular Injection Into the Knee. M. Morgen, D. Tung, B. Boras, W. Miller, AM. Malfait, and M. Tortorella. Annual Meeting of the American Association of Pharmaceutical Scientists. Washington DC, Oct 23-27, 2011.

OARSI 2011:
A Role for Chemokines and NGF in Pain Generation in a Murine Model of Osteoarthritis. R.E. Miller, P. Tran, N. Ghoreishi-Haack, R. Das, AM. Malfait. OARSI World Congress, San Diego, CA, Sept 15-18, 2011.

ORS 2011:
Structure Analysis Reveals the Vulnerability of the ADAMTS-5 Active Site. Huey-Sheng Shieh, Alfredo G. Tomasselli, Karl J. Mathis, Mark E. Schnute, Scott S. Woodard, Nicole Caspers, Jennifer M. Williams, James R. Kiefer, Grace Munie, Anne-Marie Malfait, and Micky D. Tortorella. Orthopedic Research Society Annual Meeting. Long Beach, CA, Jan 13-16, 2011.

ACR 2010:
A Role for PACE4 in Pain in Mice and Humans: Pain Phenotype of a PACE4 Null Mutant and Genetic Association with Knee Osteoarthritis Pain. Anne-Marie Malfait, Albert B Seymour, Ana M Valdes, Linda S Wood, Kathryn Durham, Micky Tortorella, Nigel K Arden, Frances L Vaughn, Paul E Leaverton, Deborah J Hart, Robert E Sorge,Susana G Sotocinal, Ara Schorscher-Petcu, Jeffrey S Mogil. ACR/ARHP Annual Scientific Meeting, Atlanta, GA, Nov 6-11, 2010.

OARSI 2010:
Destabilization of the Medial Meniscus as a Model for the Study of Pain Pathways Associated with Development of Murine Osteoarthritis. R. Das, A. Plaas, J.D. Sandy, M.D. Tortorella, AM. Malfait. OARSI World Congress, Brussels, Belgium, Sept 23-26, 2010.

Effects of Dynamic Loading on Injured Articular Cartilage in vitro and in vivo. R.E. Miller, Y. Li, J. Li, AM. Malfait, J. Sandy, A. Plaas, H.-H. Hung, E. Frank, A. Grodzinsky. OARSI World Congress, Brussels, Belgium, Sept 23-26, 2010.

Healthy Minds, Healthy Joints: Defining a Novel Role for BACE1 in Cartilage Erosion. M. Tortorella, A. Tomasselli, L. Song, R. TenBrink, C. Anglin, AM. Malfait. OARSI World Congress, Brussels, Belgium, Sept 23-26, 2010.

ORS 2010:
Quantification of Aggrecan Fragments in Synovial Fluid and Urine Using a High-Throughput LC/MS/MS Assay. AM Malfait, MD Tortorella, CP Anglin, L Branson, DR Dufield, S Settle, M Murphy, T Sunyer, and O Nemirovskiy. Orthopedic Research Society Annual Meeting. New Orleans, LA, March 6-9, 2010.

IASP 2010:
Destabilization of the medial meniscus as a model for dissecting pain pathways associated with the development of murine osteoarthritis. Das R, J. Li, Plaas A, Sandy JD, Tortorella M, Malfait AM. International Association for the Study of Pain. 13th World Congress on Pain, Montreal, Canada, Aug 30-Sept 2, 2010.

ORS 2009:
ADAMTS-5 Deficient Mice are Resistant to Mechanical Allodynia Following Medial Meniscus Destabilization as a Model of Osteoarthritis. Anne-Marie Malfait, Micky Tortorella, Jean-Sebastien Austin, Kimberly Shevlin, James Hartke, and Jeffrey S Mogil. Orthopedic Research Society Annual Meeting. Las Vegas, NV, Feb 22-25, 2009.