Publications

Preprints available now:

1. Lezgiyeva K, Liu J, Nguyen K, DeLisle MM, Ko FC, Fullam S, Obeidat AM, Turecek J, Alkislar I, Lehnert BP, Martinez-Garcia RI, Sivakumar R, Choi J, Mazor O, Garibyan L, Sharma N, Emanuel AJ, Malfait AM, Miller RE, Ginty DD. Fast-conducting mechanonociceptors uniquely engage reflexive and affective pain circuitry to drive protective responses. bioRxiv [Preprint]. 2025 Nov 20:2025.11.11.687663. doi: 10.1101/2025.11.11.687663. PMID: 41292888; PMCID: PMC12642651.

2. Vanoye CG, Ren D, Belmadani A, Malfait AM, Miller RJ, George AL. Combining automated patch clamp with optogenetics enables selective recording of DRG neurons subtypes. bioRxiv [Preprint]. 2026 Mar 9:2026.03.05.709933. doi: 10.64898/2026.03.05.709933. PMID: 41958971; PMCID: PMC13060909.

3. Michael R. Mazzucco, Bella Mehta, Jenelys Ruiz-Ortiz, Caryn Hale, Fuadur Omi, Purva Singh, Ruoxi Yuan, Samantha Lessard, Eun Kyung Song, Mengrui Zhang, Shady Younis, William H. Robinson, Daniel Ramirez, Edward DiCarlo, Wei Wang, Thomas Carroll, Jose Rodriguez, Peter Sculco, Xiaoshun Li, YiYuan Wu, Robert B.Darnell, Martin Lotz, Rachel E. Miller, Tristan Maerz, Anne-Marie Malfait, Accelerating Medicines Partnership: RA/SLE Network (AMP RA/SLE), The RE-JOIN Investigators, Miguel Otero, Dana E. Orange. Synovial transcriptional clusters link cartilage degeneration to cell-type-specific gene expression in knee osteoarthritis 2026, under review. 

For a full list of publications, see PubMed.

1. Obeidat AM, Newton MD, Li J, Hu B, Ishihara S, Lammlin L, Junginger LM, Farrell EC, Wang L, Ko FC, Miller RJ, Scanzello CR, Maerz T, Miller RE, Malfait AM. Nerve growth factor is sufficient to cause multiple osteoarthritis-relevant pathological features in naïve murine knee joints. Arthritis Rheumatol. 2026 Apr 6. doi: 10.1002/art.70168. Epub ahead of print. PMID: 41940477.

2. Burt KG, South SM, Adamczyk NS, Nguyen V, Ishihara S, Zhou C, Sharp KL, Kim SY, Rapp AE, Hu B, Murphy LA, Hung LY, Herbert D, Baker JF, Mauck RL, Griffin TM, Malfait AM, Miller RE, Scanzello CR. CD14 Plays a Critical Role in Pain and Inflammation Across Multiple Models of Post-traumatic Osteoarthritis. Arthritis Rheumatol. 2026 Feb 24. doi: 10.1002/art.70100. Epub ahead of print. PMID: 41735778.

3. Adamczyk NS, Ishihara S, Obeidat AM, Hoffman DB, David BT, Ren D, Miller RJ, Malfait AM, Miller RE. FM-dye inhibition of Piezo2 relieves mechanically evoked pain in mouse models of acute inflammatory and osteoarthritic knee pain. Br J Pharmacol. 2026 Jan 5:10.1111/bph.70306. doi: 10.1111/bph.70306. Epub ahead of print. PMID: 41491074; PMCID: PMC12879056.

4. Haelterman NA, Akopian AN, Allen KD, Cruz-Almeida Y, Donnelly CR, Lee B, Lenzi R, Malfait AM, Mancini M, Martone ME, Wagenaar JB, Worley KC; RE-JOIN Consortium. Designing and implementing solution-oriented team science initiatives-a chronic pain example. Front Pain Res (Lausanne). 2025 Dec 16;6:1669072. doi: 10.3389/fpain.2025.1669072. PMID: 41477302; PMCID: PMC12748165.

5. Otero M, Gomez IL, Sakamoto T, Okuno Y, Kenvisay C, Olmer M, Swahn H, Orange DE, Mehta B, Omi F, DiCarlo EF, Ramirez DC, Obeidat A, Malfait AM, Kulkarni P, Dalton RP 3rd, Abbas M, Cruz-Almeida Y, Allen KD, Haelterman NA; RE-JOIN Consortium Investigators; Lotz MK. Human Knee as an Organ: Joint Tissue Collection, Processing, and Scoring for Multimodal Analyses. Lab Invest. 2026 Feb;106(2):104269. doi: 10.1016/j.labinv.2025.104269. Epub 2025 Dec 2. PMID: 41344441.

6. Harkey MS, Costello KE, Mehta B, Wen C, Malfait AM, Madry H, Patterson B. Artificial intelligence in osteoarthritis research: summary of the 2025 OARSI pre-congress workshop. Osteoarthr Cartil Open. 2025 Sep 22;7(4):100687. doi: 10.1016/j.ocarto.2025.100687. PMID: 41078570; PMCID: PMC12510192.

7. Newton MD, Swahn H, Orange DE, Lesnak JB, Price TJ, Malfait AM, Miller RE, Lotz MK; RE-JOIN Consortium Investigators; Maerz T. Cross-platform transcriptomic data integration identifies an overactive neuro-immune signature in human osteoarthritis synovium. Osteoarthritis Cartilage. 2026 Apr;34(4):589-600. doi: 10.1016/j.joca.2025.08.013. Epub 2025 Aug 30. PMID: 40889615; PMCID: PMC13112359.

8. Vanlerberghe R, Colige A, Malfait AM, Syx D, Malfait F. ADAMTS2: More than a procollagen N-proteinase. Genes Dis. 2025 May 13;12(6):101686. doi: 10.1016/j.gendis.2025.101686. PMID: 40837410; PMCID: PMC12362006.

9. Hoffman DB, Miller RE, Malfait AM. Pain mechanisms in osteoarthritis: recent discoveries and opportunities ahead. Connect Tissue Res. 2025 Sep;66(5):359-366. doi: 10.1080/03008207.2025.2531414. Epub 2025 Aug 8. PMID: 40778733; PMCID: PMC12392683.

10. Ishihara S, Miller RE, Malfait AM. Assessment of Knee Hyperalgesia in Mice using Pressure Application Measurement. J Vis Exp. 2025 Jun 13;(220):10.3791/68480. doi: 10.3791/68480. PMID: 40587399; PMCID: PMC12237626.

11. Geraghty T, Ishihara S, Obeidat AM, Adamczyk NS, Hunter RS, Li J, Wang L, Lee H, Ko FC, Malfait AM, Miller RE. Acute systemic macrophage depletion in osteoarthritic mice alleviates pain-related behaviors and does not affect joint damage. Arthritis Res Ther. 2024 Dec 20;26(1):224. doi: 10.1186/s13075-024-03457-9. PMID: 39707543; PMCID: PMC11660666.

12. Obeidat AM, Ishihara S, Li J, Lammlin L, Junginger L, Maerz T, Miller RJ, Miller RE, Malfait AM. Intra-Articular Sprouting Of Nociceptors Accompanies Progressive Osteoarthritis: Comparative Evidence In Four Murine Models. bioRxiv 2023.06.30.547216; doi: https://doi.org/10.1101/2023.06.30.547216 

13. Vroman R, Hunter R, Wood MJ, Davis OC, Malfait Z, George DS, Ren D, Tavares-Ferreira D, Price TJ, Malfait AM, Malfait F, Miller RE, Syx D. The matrisome of the murine and human dorsal root ganglion: a transciptomal approach. Front. Mol. Neurosci. 2023;16 [https://doi.org/10.1101/2022.10.22.513341]

14. Colman M, Syx D, de Wandele I, Rombaut L, Wille D, Malfait Z, Meeus M, Malfait AM, Van Oosterwijck J, Malfait F. Sensory profiling in classical Ehlers-Danlos syndrome: a case-control study revealing pain characteristics, somatosensory changes, and impaired pain modulation. J Pain. 2023 [PubMed]

15. Obeidat AM, Wood MJ, Ishihara S, Li J, Wang L, Ren D, Bennett DA, Miller RJ, Malfait AM, Miller RE. Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis. Nature Communications. 2023;14:2479. [PubMed]

16. Geraghty T, Obeidat AM, Ishihara S, Wood MJ, Li J, Lopes EBP, Scanzello CR, Griffin TM, Malfait AM, Miller RE. Age-associated changes in knee osteoarthritis, pain-related behaviors, and dorsal root ganglia immunophenotyping of male and female mice. Arthritis & Rheumatology, 2023. [PubMed]

17. Wang L, Ishihara S, Li J, Miller RE, Malfait AM. Notch signaling is activated in knee-innervating dorsal root ganglia in experimental models of osteoarthritis joint pain. Arthritis Research & Therapy. 2023;25:63. [PubMed]

18. Ishihara S, Obeidat AM, Wokosin DL, Ren D, Miller RJ, Malfait AM, Miller RE. The role of intra-articular neuronal CCR2 receptors in knee joint pain associated with experimental osteoarthritis in mice. Arthritis Research & Therapy. 2021;23:103. [PubMed]

19. Geraghty T, Winter DR, Miller RJ, Miller RE, Malfait AM. Neuroimmune interactions and osteoarthritis pain: focus on macrophages. PAIN Reports. 2021;6(1):e892. [PubMed]

20. Syx D, Miller RE, Obeidat AM, Tran PB, Vroman R, Malfait Z, Miller RJ, Malfait F, Malfait AM. Pain-related behaviors and abnormal cutaneous innervation in a murine model of classical Ehlers-Danlos syndrome. Pain. 2020;161(10):2274-83. [PubMed]

21. Malfait AM, Miller RE, Block JA. Targeting neurotrophic factors: Novel approaches to musculoskeletal pain. Pharmacol Ther. 2020;211:107553. [PubMed]

22. Malfait AM, Miller RE. Why we should study osteoarthritis pain in experimental models in both sexes. Osteoarthritis Cartilage. 2020;28(4):397-399. [PubMed]

23. Miller RE, Tran PB, Ishihara S, Syx D, Ren D, Miller RJ, Valdes AM, Malfait AM. Microarray Analyses of the Dorsal Root Ganglia Support a Role for Innate Neuro-Immune Pathways in Persistent Pain in Experimental Osteoarthritis. Osteoarthritis Cartilage. 2020;28(5):581-592. [PubMed]

24. Miller RJ, Malfait AM, Miller RE. The innate immune response as a mediator of osteoarthritis pain. Osteoarthritis Cartilage. 2020;28(5):562-571. [PubMed]

25. Alles SRA, Malfait AM, Miller RJ. Chemo- and Optogenetic Strategies for the Elucidation of Pain Pathways. The Oxford Handbook of the Neurobiology of Pain. Online publication date Nov 2019. [OxfordHandbooks]

26. Miller RE, Scanzello CR, Malfait AM. An emerging role for Toll-like receptors at the neuroimmune interface in osteoarthritis. Seminars in Immunopathology. 2019;41(5):583-594. [PubMed]

27. Obeidat AM, Miller RE, Miller RJ, Malfait AM. The Nociceptive Innervation Of The Normal And Osteoarthritic Mouse Knee. Osteoarthritis Cartilage. 2019;27(11):1669-1679. [PubMed]

28. Chua JR, Jamal S, Riad M, Castrejon I, Malfait AM, Block JA, Pincus T. Disease burden in osteoarthritis (OA) is similar to rheumatoid arthritis (RA) at initial rheumatology visit and significantly greater 6-months later. Arthritis Rheumatol. 2019;71(8):1276-1284. [PubMed]

29. Miller RE, Ishihara S, Tran PB, Golub SB, Last K, Miller RJ, Fosang AJ, Malfait AM. An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2. JCI Insight. 2018;3(6):e95704. [PubMed]

30. Miller RE, Kim YS, Tran PB, Ishihara S, Dong X, Miller RJ, Malfait AM. Visualization of Peripheral Neuron Sensitization in a Surgical Mouse Model of Osteoarthritis by In Vivo Calcium Imaging. Arthritis Rheumatol. 70:88. 2018. [PubMed]

31. Miller RE, Block JA, Malfait AM. What is new in pain modification in osteoarthritis. Rheumatology. 57:iv99. 2018. [PubMed]

32. Syx D, Tran PB, Miller RE, Malfait AM. Peripheral Mechanisms Contributing to Osteoarthritis Pain. Curr Rheum Rep. 20:9. 2018. [PubMed]

33. Malfait AM, Pincus T. Pain in rheumatic diseases. Clin Exp Rheumatol. 35:1. 2017. [PubMed]

34. Miller RE, Malfait AM, Block JA. Current status of nerve growth factor antibodies for the treatment of osteoarthritis pain. Clin Exp Rheumatol. 35:85. 2017. [PubMed]

35. Miller RE, Miller RJ. Is cannabis an effective treatment for joint pain? Clin Exp Rheumatol. 35:59. 2017. [PubMed]

36. Malfait AM. Why we should study pain in animal models of rheumatic diseases. Clin Exp Rheumatol. 35:37. 2017. [PubMed]

37. Sambamurthy N, Nguyen V, Smalley R, Xiao R, Hankenson K, Gan J, Miller RE, Malfait AM, Dodge GR, Scanzello CR. Chemokine receptor-7 (CCR7) deficiency leads to delayed development of joint damage and functional deficits in a murine model of osteoarthritis. J Orthop Res. In Press. 2017. [PubMed]

38. Miller RE, Ishihara S, Bhattacharyya B, Delaney A, Menichella DM, Miller RJ, Malfait AM. Chemogenetic Inhibition of Pain Neurons in a Mouse Model of Osteoarthritis. Arthritis Rheumatol. 69:1429. 2017. [PubMed][Editorial]

39. Miller RE and Malfait AM. Can we target CCR2 to treat osteoarthritis? The trick is in the timing! Osteoarthritis Cartilage. 25:799. 2017. [PubMed]

40. Malfait AM and Miller RJ. Emerging Targets for the Management of Osteoarthritis Pain. Curr Osteoporos Rep. 14:260. 2016. [PubMed]

41. Vincent T, Malfait AM. Time to be positive about negative data? Osteoarthritis Cartilage. 25:351. 2017. [PubMed]

42. Miotla Zarebska J, Chanalaris A, Driscoll C, Burleigh A, Miller RE, Malfait AM, Stott B, Vincent TL. CCL2 and CCR2 regulate pain-related behaviour and early gene expression in post-traumatic murine osteoarthritis but contribute little to chondropathy. Osteoarthritis Cartilage. 25:406-412. 2017. [PubMed]

43. Miller RE, Block JA, Malfait AM. Nerve growth factor blockade for the management of osteoarthritis pain: what can we learn from clinical trials and preclinical models? Curr Opin Rheumatol. 29:110-118. 2017. [PubMed]

44. Tran PB, Miller RE, Ishihara S, Miller RJ, Malfait AM. Spinal Microglial Activation in a Murine Surgical Model of Knee Osteoarthritis. Osteoarthritis Cartilage. 25:718-726. 2017. [PubMed][Editorial]

45. Miller RE, Tran PB, Ishihara S, Larkin J, Malfait AM. Therapeutic effects of an anti-ADAMTS-5 antibody on joint damage and mechanical allodynia in a murine model of osteoarthritis. Osteoarthritis Cartilage. 24:299. 2016. [PubMed]

46. Malfait AM. Osteoarthritis year in review 2015: biology. Osteoarthritis Cartilage. 24:21. 2016. [PubMed]

47. Miller RE, Belmadani A, Ishihara S, Tran PB, Ren D, Miller RJ, Malfait AM. Damage-Associated Molecular Patterns Generated in Osteoarthritis Directly Excite Murine Nociceptive Neurons through Toll-like Receptor 4. Arthritis & Rheumatology. 67(11):2933-43. 2015. [PubMed]

48. Miller RE, Tran PB, Obeidat AM, Raghu P, Ishihara S, Miller RJ, Malfait AM. The Role of Peripheral Nociceptive Neurons in the Pathophysiology of Osteoarthritis Pain. Current Osteoporosis Reports. 13(5):318-26. 2015. [PubMed]

49. Malfait AM and Little CB. On the predictive utility of animal models of osteoarthritis. Arthritis Res Ther. 17:225. 2015. [PubMed]

50. Chen S, Cao P, Dong N, Peng J, Zhang C, Wang H, Zhou T, Yang J, Zhang Y, Martelli EE, Naga Prasad SV, Miller RE, Malfait AM, Zhou Y, Wu Q. PCSK6-mediated corin activation is essential for normal blood pressure. Nature Medicine. 21(9):1048-53. 2015. [PubMed]

51. Larkin J, Lohr TA, Elefante L, Shearin J, Matico R, Su JL, Xue Y, Liu F, Genell C, Miller RE, Tran PB, Malfait AM, Maier CC, Matheny CJ. Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification. Osteoarthritis Cartilage. 23(8):1254-66. 2015. [PubMed]

52. Miller RE, Miller RJ, Malfait AM. Osteoarthritis joint pain: The cytokine connection. Cytokine. 70(2):185-93. 2014. [PubMed]

53. Malfait AM, Schnitzer TJ. Towards a mechanism-based approach to pain management in osteoarthritis. Nat Rev Rheumatol. 9(11):654-664. 2013. [PubMed]

54. Malfait AM, Little CB, McDougall JJ. A commentary on modelling osteoarthritis pain in small animals. Osteoarthritis Cartilage. 21(9):1316-1326. 2013. [PubMed]

55. Miller RE, Lu Y, Tortorella MD, Malfait AM. Genetically Engineered Mouse Models Reveal the Importance of Proteases as Osteoarthritis Drug Targets. Curr Rheumatol Rep. 15(9):350. 2013. [PubMed]

56. Miller RE, Tran PB, Das R, Ghoreishi-Haack N, Ren D, Miller RJ, Malfait AM. CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis. PNAS. 109(50):20602-7. 2012. [PubMed]

57. Morgen M, Tung D, Boras B, Miller W, Malfait AM, Tortorella MD. Nanoparticles for Improved Local Retention after Intra-Articular Injection into the Knee Joint. Pharmaceutical Research. 30(1):257-68. 2013. [PubMed]

58. Malfait AM, Seymour AB, Gao F, Tortorella MD, Le Graverand-Gastineau MPH, Wood LS, Doherty M, Doherty S, Zhang W, Arden NK, Vaughn FL, Leaverton PE, Spector TD, Hart DJ, Maciewicz RA, Muir KR, Das R, Sorge RE, Sotocinal SG, Schorscher-Petcu A, Valdes AM, Mogil JS. A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype. Annals of the Rheumatic Diseases. 71(6):1042-8. 2012. [PubMed]

59. Nair A, Kanda V, Bush-Joseph C, Verma N, Chubinskaya S, Mikecz K, Glant TT, Malfait AM, Crow MK, Spear GT, Finnegan A, Scanzello CR. Synovial fluid from patients with early osteoarthritis modulates fibroblast-like synoviocyte responses to TLR-4 and TLR-2 ligands via soluble CD14. Arthritis Rheum. 64(7):2268-77. 2012. [PubMed]

60. Malfait AM. Modelling pain in post-traumatic osteoarthritis of the knee. Pain. 153(2):257-8. 2012. [PubMed]

61. Shieh HS, Tomasselli AG, Mathis KJ, Schnute ME, Woodard SS, Caspers N, Williams JM, Kiefer JR, Munie G, Wittwer A, Malfait AM, Tortorella MD. Structure analysis reveals the flexibility of the ADAMTS-5 active site. Protein Sci. 20(4):735-44. 2011. [PubMed]

62. Malfait AM, Ritchie J, Gil AS, Austin JS, Hartke J, Qin W, Tortorella MD, Mogil JS. ADAMTS-5 deficient mice do not develop mechanical allodynia associated with osteoarthritis following medial meniscal destabilization. Osteoarthritis Cartilage. 18(4):572-80. 2010. [PubMed]

63. Byun S, Tortorella MD, Malfait AM, Fok K, Frank EH, Grodzinsky AJ. Transport and equilibrium uptake of a peptide inhibitor of PACE4 into articular cartilage is dominated by electrostatic interactions. Arch Biochem Biophys. 499(1-2):32-9. 2010. [PubMed]

64. Zack MD, Melton MA, Stock JL, Storer CE, Barve RA, Minnerly JC, Weiss DJ, Stejskal JA, Tortorella MD, Turk JR, Shevlin KM, Malfait AM. Reduced incidence and severity of experimental autoimmune arthritis in mice expressing catalytically inactive A disintegrin and metalloproteinase 8 (ADAM8). Clin Exp Immunol. 158(2):246-56. 2009. [PubMed]

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